Not known Facts About mif
Not known Facts About mif
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Macrophage migration inhibitory aspect (MIF) is among the first described cytokines, identified for a soluble immune cell-derived element in excess of 50 decades ago in 1966. comparable to cytokines including tumor necrosis element (TNF), MIF's variety of functions has exceeded what's implied by the historic identify (5, 6). The MIF gene was cloned in 1989, and subsequent scientific tests have demonstrated a wide range of roles for MIF. MIF is a truly pleiotropic inflammatory cytokine that may be expressed by a number of cells, and is particularly a significant upstream mediator of innate immunity.
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The receptor that mediated MIF exercise remained elusive until a analyze in 2003, which used a cDNA library and fluorescently conjugated MIF to monitor for a receptor and determined CD74 given that the MIF receptor. The authors described that MIF certain to the extracellular area of CD74, causing extracellular signal-regulated kinase (ERK) pathway activation (twenty five).
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The Glide module in Schrödinger was employed for molecular docking calculations [28]. The tautomers and protonation states on the ligands were being produced at pH =7.4 by LigPrep in Schrödinger after which you can docked into the binding website of MIF by Glide in more precision (XP) scoring manner. The bounding box was centered over the cocrystallized ligand.
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